精神疾病對高血壓治療與療程的影響

基於80+篇研究的循證醫學臨床指南

10

精神疾病類別

5.2倍

最高不依從風險 (PTSD)

62%

失眠患者低依從率

80+

研究文獻基礎

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疾病影響比較分析

疾病影響程度盛行率依從性影響血壓控制嚴重程度

研究證據基礎

研究方法學

  • 隨機對照試驗
  • 觀察性研究
  • Meta分析
  • 縱向隊列研究

證據品質

高品質循證醫學證據

基於80+篇英文研究文獻

來源：PubMed、Cochrane、專業期刊

主要發現摘要

最高風險

創傷後壓力症候群 (PTSD) 具有最高的藥物不依從風險，達5.2倍

最佳介入

整合式心理+藥物治療可顯著改善依從性和血壓控制

臨床意義

精神疾病篩檢應成為高血壓治療的標準流程

引用研究文獻

  1. Clinical correlates of medication adherence in individuals with bipolar disorder and comorbid hypertension. Link
  2. Clinical Correlates of Medication Adherence to Antihypertensives and Bipolar Medications in Individuals With Hypertension and Bipolar Disorder. Link
  3. Using mHealth to improve adherence and reduce blood pressure in individuals with hypertension and bipolar disorder (iTAB-CV): study protocol for a 2-stage randomized clinical trial. Link
  4. Drug adherence and psychological factors in patients with apparently treatment‐resistant hypertension. Link
  5. Depressive Symptoms and Medication Adherence: Association in Hypertensive Individuals (Systematic Review). Link
  6. PTSD increases cardiovascular disease and cardiovascular mortality risk: Risk for Incident Hypertension Associated with PTSD in Veterans. Link
  7. A Critical Review of Medication Adherence in Hypertension: Barriers and Facilitators. Link
  8. Pattern and Prevalence of Psychiatric Comorbidity in Hypertensive Patients. Link
  9. Factors affecting treatment adherence among patients with hypertension (behavioral economics, delay discounting, self-efficacy). Link
  10. Anti-hypertensive medications and PTSD incidence in a population-based sample. Link
  11. Blood pressure status, quality of life, and emotional states: adherence, anxiety and quality of life in hypertensive women. Link
  12. Mental health of hypertensive patients and its association with psychiatric comorbidities (type 2 diabetes, hypertension, anxiety, depression). Link
  13. Association of mental health and medication adherence with blood pressure control in primary care patients with hypertension. Link
  14. Antihypertensive Medication Adherence and Blood Pressure Control in Psychotic Patients. Link
  15. Therapeutic Drug Monitoring for Antipsychotic Medication to Estimate Drug Adherence. Link
  16. The Effect of Dietary Approaches to Stop Hypertension on children with ADHD. Link
  17. Associations between adherence to the Taiwan Daily Food Guide and psychiatric morbidity: A population-based study in Taiwan. Link