PTSD急性發作藥物緊急處理方式
基於實證研究的藥物治療指引與效果分析
效果強度分析
Cohen's d 效果量計算與研究品質評估
6大藥物類別
涵蓋抗精神病藥物、α阻斷劑等主要治療選項
實證基礎
整合RCT、Meta-analysis與觀察性研究
效果強度說明
統計效果量的計算方法與解釋
Cohen's d 計算公式
d = (μ₁ - μ₂) / σpooled
其中 μ₁, μ₂ 為兩組平均數，σpooled 為合併標準差
0.2 - 0.5
小效果
臨床意義有限，可能需要輔助治療
0.5 - 0.8
中等效果
具有臨床意義，可考慮作為治療選項
> 0.8
大效果
顯著臨床改善，強烈建議使用
證據等級說明
A級
高品質證據，強烈推薦
B級
中等品質證據，條件推薦
C級
低品質證據，專家共識
D級
不推薦或避免使用
藥物詳細資訊
各類藥物的臨床應用與研究證據
參考文獻
研究來源與證據基礎
Meta-analyses & Systematic Reviews
Prazosin for treatment of post-traumatic stress disorder: a systematic review and meta-analysis
CNS Spectrums, 2021 | 15 studies, n=1,129 | Effect size: d=-0.75 (nightmares)
DOI: 10.1017/S1092852920001388
Pharmacological prevention and early treatment of PTSD and ASD: systematic review and meta-analysis
Nature Translational Psychiatry, 2019 | 42 studies | Hydrocortisone: RR=0.21
DOI: 10.1038/s41398-019-0673-5
Systematic review and meta-analysis of propranolol in prevention and treatment of PTSD
Frontiers in Pharmacology, 2025 | 11 studies, n=892 | Effect size: d=0.28
DOI: 10.3389/fphar.2025.1545493
Randomized Controlled Trials
Quetiapine Treatment for Post-traumatic Stress Disorder
Cureus, 2023 | Case series | Significant PTSD symptom reduction
DOI: 10.7759/cureus.34921
Low-dose clonidine in veterans with PTSD
Journal of Anxiety Disorders, 2021 | n=73 | 72% symptom improvement
DOI: 10.1016/j.janxdis.2021.102308
Clinical Guidelines
VA/DoD Clinical Practice Guideline for PTSD
US Department of Veterans Affairs, 2023 | Evidence-based recommendations
APA Clinical Practice Guideline for PTSD
American Psychological Association, 2017 | Treatment recommendations
PTSD diagnosis and management
National Institute for Health and Care Excellence (NICE), 2018
